The diagnosis and rescue of acute poisoning constitute a crucial topic in clinical emergency medicine. Millions of drug and toxicant poisoning incidents occur annually across the world. Timely and accurate toxicological analysis and identification directly influence the choice of clinical treatment plans and are of vital importance in clinical emergency rescue. Currently, the emergency medical staff in tertiary general hospitals undertake a large amount of clinical treatment work for acute poisoning and medical rescue tasks for mass poisoning incidents. However, when confronted with complex clinical diseases such as poisoning, the deficiencies in professional knowledge such as clinical toxicology, toxicology, toxicokinetics, and toxicant detection among the existing poisoning treatment teams are exposed, which has become a shortcoming in poisoning treatment. In the past decade, with the rapid development of clinical toxicology and the gradual improvement of toxicant detection capabilities, it is urgent to build a professional poisoning treatment team, especially to cultivate technical talents for the identification of unknown toxicants.

Practice-based education is an important carrier of higher education teaching work under the new situation and an effective way to promote the formation of all-round education involving the whole staff and the entire process. This project intends to combine professional characteristics and promote the implementation of a trinity practice-based education model of "meeting clinical needs, highlighting professional features, and striving for innovative development". Through diversified carriers such as volunteer services, clinical practice, and professional internships, an innovative talent cultivation system for the identification of unknown toxicants in poisoning treatment will be established to achieve the goals of practice-based education and moral cultivation. The development of new technologies and projects in clinical actual work is one of the difficulties in clinical work and also a key point in the construction of the practice-based education system.

In response to the pain points and difficulties in the identification technology of unknown toxicants in poisoning rescue and the cultivation of relevant talents, the concept of the whole process of practice-based education and talent cultivation will be implemented. By means of innovating the methods and approaches of practice-based education, relying on strengthening the construction of practice-based education bases, and actively mobilizing and integrating various resources inside and outside the school, a joint force for practice-based education will be formed to build a long-term mechanism. Based on this, the application team pioneeringly applies the identification technology of unknown toxicants to clinical practice and constructs a rapid, comprehensive, and stable identification technology for unknown toxicants. By combining symptom analysis of patients with blood test results, the toxicant causing patient poisoning can be determined within 30 minutes, solving the "mystery of the unknown" and providing accurate evidence for clinical treatment, thus constructing a technical system for the identification of unknown toxicants in poisoning treatment. Secondly, by establishing practice bases and formulating operating procedures for the identification of unknown toxicants in clinical poisoning treatment, a practical platform will be provided for students majoring in clinical pharmacy, toxicology, clinical medicine, and other related majors to increase their clinical practice experience. Furthermore, the PBL model will be adopted to carry out teaching work. By simulating poisoning cases, with the assistance of teachers, students will operate to analyze possible poisoning substances, gradually establishing a curriculum system for the talent cultivation system of the identification of unknown toxicants in poisoning treatment based on the trinity practice-based education system, realizing the talent cultivation in the direction of unknown substance screening and identification.

The application team intends to ultimately form a cultivation plan for the talent cultivation system of the identification of unknown toxicants in poisoning treatment based on the trinity practice-based education system through such means, guiding students to establish value orientations that meet social and clinical needs, enhancing students' social responsibility to serve the country and the people, improving students' professional practical abilities, and cultivating students to become young people of the era with outstanding comprehensive abilities and a strong sense of moral responsibility.

Integrating medicine and pharmacy and combining the characteristics and advantages of emergency medicine and clinical pharmacy in affiliated hospitals to construct a talent cultivation system for the identification of unknown toxicants in poisoning treatment that closely links pharmacy and clinical medicine.

Practice-based education is an important vehicle for higher education teaching work under the new situation and an effective way to promote the formation of "education involving the whole staff, the entire process, and all aspects". This project intends to combine professional characteristics and adopt a trinity practice-based education model of "meeting clinical needs, highlighting professional features, and striving for innovative development". Through diversified carriers such as volunteer services, clinical practice, and professional internships, an innovative talent cultivation system for the identification of unknown toxicants in poisoning treatment will be established. This will not only help to unify innovative thinking and social practice but also further enhance students' sense of social responsibility to serve the country and the people, cultivate their spirit of practical exploration and innovation, and develop their practical ability to solve problems.

Based on a systematic review and comprehensive analysis of the achievements in theoretical research and practical exploration of practice-based education at home and abroad, taking the talent cultivation system for the identification of unknown toxicants in poisoning treatment as an example, this project explores the construction of a technical system for the identification of unknown toxicants in poisoning treatment, formulates operating procedures for the identification of unknown toxicants in clinical poisoning treatment, establishes a curriculum system for the talent cultivation system of the identification of unknown toxicants in poisoning treatment based on the trinity practice-based education system, and establishes an operation mechanism for the "trinity" practice-based education system. Therefore, this project is innovative in terms of academic thought, practical application, and research methods.

Establish a talent cultivation system for the identification of unknown toxicants in poisoning treatment based on the trinity practice education system, including: - One set of technical system for the identification of unknown toxicants in poisoning treatment;

-One operating procedure for the identification of unknown toxicants in clinical poisoning treatment;

- One cultivation plan for the talent cultivation system of the identification of unknown toxicants in poisoning treatment based on the trinity practice education system;

- One curriculum system for the talent cultivation system of the identification of unknown toxicants in poisoning treatment based on the trinity practice education system;

- One summary report.

The talent cultivation system for the identification of unknown toxicants in poisoning treatment based on the trinity practice education system is mainly used to cultivate applied talents in the identification of unknown toxicants in poisoning treatment, and can also be taken by students majoring in clinical pharmacy and emergency medicine.

6 months

• Fellows

• Residents

• Students

The training program encompasses a wide range of clinical specialties and sub-specialties. In terms of clinical specialties, it involves emergency medicine, clinical pharmacy, and toxicology. These specialties provide the fundamental knowledge and skills required for understanding the pathophysiology of poisoning, the pharmacology of antidotes, and the mechanisms of toxicant actions. The sub-specialties covered include forensic toxicology, which plays a crucial role in the legal aspects of poisoning cases, and occupational toxicology, dealing with toxicant exposures in the workplace. Pediatric toxicology is also part of the scope, considering the unique susceptibility and manifestations of poisoning in children. Regarding the technologies, advanced analytical techniques are incorporated. Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) are utilized for the detection and identification of unknown toxicants in biological samples. Enzyme-linked immunosorbent assays (ELISA) are used for rapid screening of certain classes of toxicants. In addition, molecular biology techniques are introduced to study the genetic factors influencing the response to toxicants and the development of potential biomarkers for poisoning diagnosis and prognosis. Overall, this comprehensive training approach aims to equip professionals with the necessary expertise to handle the complex challenges in the field of poisoning treatment and the identification of unknown toxicants.

Training schedule

Monday

1st Week: Introduction & Welcome, Program overview and objectives

Weekly: MDT conferences, Complicated case study

Tuesday

Weekly: Skills training

Biweekly: Mentor one-on-one training

Wednesday

Weekly: Clinical rounds, lectures

Biweekly: seminars

Thursday

Weekly: Complicated case study, Case-based discussion

Biweekly: hands-on

Friday

Weekly: Journal club, Clinical rounds, Clinical skills training, Special task training

Last Week: Wrap-Up & Reflection, Participant presentations or discussion of key takeaways, Feedback session

Practical assessments, report submissions

Learners will get feedback via multiple channels. In practical training, instructors will offer immediate on-site feedback. For instance, during toxicant identification technique exercises, they'll correct learners' operation errors promptly. After written work, detailed written feedback will be given, covering content quality, idea flow, theory application, and referencing. It'll highlight strengths and weaknesses and suggest improvements. In group activities, peer feedback is important. Learners will evaluate each other, sharing perspectives on contributions and skills, promoting mutual learning. Periodic progress reviews and one-on-one consultations will also be arranged. Instructors will discuss learners' progress, address concerns, and provide personalized guidance, ensuring continuous support for their growth in poisoning treatment and toxicant identification.

The program is free of charge.