1. Background

Understanding the behavior and distribution of tumor-related molecules is crucial for early diagnosis and effective treatment. Traditional imaging techniques often have limitations in providing real-time and detailed information at both the in vitro and in vivo levels. Fluorescence technology has emerged as a powerful tool, offering high sensitivity and specificity. It allows for the visualization of specific molecules within tumors, enabling researchers to track their movements and interactions in real time. This can provide valuable insights into tumor progression, metastasis, and response to therapy, ultimately leading to improved patient outcomes and more personalized treatment strategies.

2. Purpose

The primary purpose of my research is to develop and optimize fluorescence-based imaging techniques for real-time visualization of tumor-associated molecules, both in vitro and in vivo. By precisely mapping the location, distribution, and dynamics of these molecules, we aim to gain a deeper understanding of the fundamental biological processes underlying tumorigenesis and progression. This knowledge could potentially identify novel biomarkers for early cancer detection, which is vital for improving patient survival rates. Additionally, we strive to monitor the real-time response of tumors to various therapeutic interventions, enabling the timely adjustment of treatment regimens to enhance their efficacy and minimize side effects. Ultimately, our research aspires to translate these technological advancements into clinical applications, thereby revolutionizing the diagnosis and treatment of cancer and improving the overall quality of life for patients.

3. Target group

This course is designed for international students pursuing careers in healthcare, medicine, and related fields. Participants will include medical students, healthcare professionals, and researchers who seek to realization and development of molecules fluorescence imaging technologies and their implications in clinical study. By the end of the program, participants will be well-prepared to engage with molecule fluorescence imaging and contribute to the future of healthcare.

1. High Sensitivity and Specificity

Our fluorescence technology allows for the detection of tumor-associated molecules with remarkable sensitivity, enabling the identification of even low-abundance biomarkers. The specific binding or interaction of fluorescent probes with target molecules ensures high specificity, minimizing false positive signals and providing accurate information about the presence and location of tumor-related molecules.

2. Real-time and Dynamic Monitoring

One of the key highlights is the ability to observe the behavior of tumor-associated molecules in real-time, both in vitro and in vivo. This dynamic monitoring provides valuable insights into the kinetics of molecular processes such as tumor cell proliferation, migration, and response to treatment. It allows us to track changes as they occur, which is crucial for understanding the temporal aspects of cancer biology and for evaluating the immediate impact of therapeutic interventions.

3. Multimodal Imaging Capability

Our approach integrates fluorescence imaging with other imaging modalities, such as MRI or CT, to combine the high-resolution anatomical information of the latter with the molecular specificity of fluorescence. This multimodal imaging strategy offers a more comprehensive view of the tumor microenvironment, facilitating a better understanding of the relationship between molecular events and macroscopic tumor characteristics. It also aids in more precise tumor localization and staging, leading to more effective treatment planning.

(1) Learn about the history and current state of molecules fluorescence imaging in medicine.

(2) Understand the process of implementing molecules fluorescence imaging in cancer diagnosis.

(3) Develop a potential biosensor for molecule imaging.

My research focuses on the development of DNA biosensors for crucial molecule fluorescence imaging in vivo or in vitro. My research aims to construct high sensitive, selective and spatio-controlled biosensor for molecule imaging with high signal-to-noise ratio.

Program Training Schedule:

Time: 9:00 AM - 10:00 PM

Duration: 1 hours

Activities:

Lecture on the history and process of molecule imaging.

Group discussion on the impacts of molecule imaging on current medicine.

Format: Lecture followed by a student-led discussion.

Break: 10:00 PM - 10:10 PM

Session Name: Design of biosensor for molecule imaging

Time: 10:10 PM - 11:00 PM

Duration: 50 minutes

Activities:

Development of biosensor and illustration of work mechanism.

Format: Group work and presentations.

Group Discussions: Dedicated time will be allotted during the program for participants to engage in open discussions about their experiences, allowing for real-time feedback and suggestions.