Background: Nucleic acid drug discovery and development has become the core of the third wave of new drug development following small molecule drugs and antibody drugs. Especially in the past 10 years, many technological breakthroughs have been achieved to overcome the druggability bottlenecks, such as chemical modification, delivery and targeting. In particular, the emergence and widespread use of mRNA vaccines during the novel coronavirus infection epidemic made nucleic acid drug discovery and development the focus of both academia and industry, as well as public awareness. Therefore, nucleic acid drugs a will lead the wave of drug development in the coming decades after nearly 10 years of development.

Purpose: Introduce the frontiers of nucleic acid drug discovery and development and activate the study passion of the audience on nucleic acids.

Target group: Graduate students and researchers

This project will give a show on the state-of-art technologies in the field of nucleic acid chemical biology.

After the introduction of the frontiers of nucleic acid drug discovery and development, I will appreciate it if someone in the audience become interested in nucleic acid research. I also would like to invite them to join the projects I am doing if possible and I could lead them to feel and practice the state-of-art technologies in the field of nucleic acid chemical biology.

Research area: Nucleic acid drugs and nucleic acid chemical biology

Research goals：Utilizing nucleic acid chemistry and chemical biology approaches to address key scientific problems in the study of nucleic acid drugs, including siRNAs, antisense oligonucleotides and nucleic acid aptamers.

Key topics: Regulation of functional nucleic acids

Projfect: Promoting bone formation via GalNAc-Aptamer targeted degradation of sclerostin

Duration: X weeks/months

1 month and 3 weeks

Daily Training Schedule:

On a certain day of the week, the tutor will arrange Training, practice or presentation works for the trainees. Time duration is about 2-3 hours one time.

Program Training Schedule:

1. Session Name: Nucleic acid drugs

Time Duration: (1 day)

Activities: Basic knowledge training

Format: Class teaching

2. Session Name: siRNA

Time Duration: (1 day)

Activities: Basic knowledge training

Format: Class teaching

3. Session Name: Antisense oligonucleotide

Time Duration: (1 day)

Activities: Basic knowledge training

Format: Class teaching

4. Session Name: Aptamer

Time Duration: (1 day)

Activities: Basic knowledge training

Format: Class teaching

5. Session Name: Nucleic acid stapler

Time Duration: (1 day)

Activities: Basic knowledge training

Format: Class teaching

6. Session Name: Experimental practice

Time Duration: (1 day)

Activities: The trainees will visit our laboratory and do some easy experiment.

Format: practice

7. Session Name: Presentation

Time Duration: (1 day)

Activities: The trainee will have a presentation about what they learn.

Format: small academic forum

Report and Presentation, Qualified certificates will be provided for the one who is excellent.