This program is tailored to train researchers and students in assisted reproduction and mitochondrial medicine. It aims to equip participants with both scientific research of mitochondrial diseases and the technology of mitochondrial replacement therapy. The target group includes graduate students, research fellows, and postdoctoral researchers passionate about assisted reproduction medicine.

· Access to advanced laboratory technology, including intracytoplasmic sperm injection (ICSI) and mitochondrial replacement therapy.

· Assisted Reproductive Technologies (In Vitro Fertilization - Embryo Culture, Oocytes and embryo Vitrification,  Embryo transfer )

· Real-time follow up the research strategies and methods of mitochondrial diseases

· Opportunities to publish articles or abstracts in peer-reviewed journals and present research posters or papers at conferences

· Weekly mentorship meetings with Prof. GUAN and a multidisciplinary research team

· Understand the research strategies of Mitochondrial disease 

· Develop proficiency in laboratory techniques, such as ICSI and spindle-chromosomal complex transfer

· Gain experience in assisted reproduction laboratory procedures

Research focus:

· Preclinical study of novel assisted reproduction techniques to block mitochondrial genetic diseases

· Ferroptosis in endometriosis

· Oxidative stress in endometriosis

Projects:

1. Methyl 3,4-dihydroxybenzoate alleviates oxidative damage in granulosa cells of endometriosis

2. Mechanism of UC-MSC transcellular mitochondrial transport to improve

energy metabolism of ovarian granulosa cells and interfere with ovarian senescence

Graduate students：

Candidates must be enrolled in a Master's, M.D. or Ph.D. program in biomedicine, reproductive medicine or a related field. Basic proficiency in English is required.

Researcher fellows：

Applicants should have an advanced degree (M.Sc. M.D. Ph.D. or equivalent) in a biomedical discipline and reproductive medicine with some prior research experience. Fluency in English is mandatory.

Doctors：

Candidates must hold an M.D. degree with biomedicine, reproductive medicine. Research experience is not mandatory but is a strong advantage. Applicants must be fluent in English.

Postdocs：

Postdoctoral fellows should have a Ph.D. in biomedicine, reproductive medicine, or an M.D. with clinical training in medicine, or the equivalent of education, training and experience. Candidates should be fluent in English.

Daily Training Schedule:

Monday:

9:00 AM – 12:00 AM: Lecture on Basics of Mitochondrial disease

6:00 PM-9:00 PM: Journal club: literature sharing session and scientific research discussion meeting.

Tuesday:

8:00 AM – 12:00 PM: Assisted reproduction laboratory training

1:30 PM – 5:00 PM: lab training: ICSI

Wednesday:

11:30 AM – 12:30 PM: One-on-one mentorship meetings

1:30 PM – 5:00 PM: lab training: spindle-chromosomal complex transfer

Program Training Schedule:

1. Introduction & Welcome

Time Duration: (1 day)

Activities:

· Workshop overview and objectives

· Introduction of facilitators/tutors

2. Practical/Hands-On Session

Time Duration: (3 weeks)

Activities:

· Demonstrations of research tools or methods (e.g. lab equipment, software)

· Practice exercises where participants replicate a research technique

· Guided small-group activities for mitochondrial genetic diseases research or analyzing data.

Assessment Methods:

· Practical assessments during lab sessions: ICSI and spindle-chromosomal complex transfer

· Submission of a final research report summarizing lab work

Feedback for Participants:

Participants can submit anonymous feedback via an online form at the end of the program. One-on-one feedback sessions will also be scheduled midway through the program.

The program is free of charge.