The program aims to train early career otolaryngology physicians and students to conduct otolaryngology-related clinical research. In order to improve the clinical research ability of otolaryngologists and ensure that patients get more scientific and effective treatment, we specially carry out this training program. Target groups include graduate students, researchers, and residents who are passionate about otolaryngology.

· Weekly tutor meetings with Professor Zhou and the entire otolaryngology research team.

· Complete training covering the fundamentals of clinical research, design principles, implementation procedures, data analysis and ethical review.

· Through case analysis and simulation exercise, the practical application ability of clinical research scheme is improved.

· Understand the latest clinical research trends and improve the participants' understanding of the entire clinical research process.

· Real-time participation in clinical trials and translational research projects.

· Opportunity to present research posters or papers at the conference.

· Understand the basic concepts, design principles and research methods of clinical research.

· To cultivate the ability of participants to formulate scientific and reasonable clinical research programs according to the characteristics of otolaryngology diseases.

· Understand cutting-edge otolaryngology clinical research projects, obtain database information, and master data analysis skills

· Learn how to combine clinical research with laboratory research.

· Strengthen the ethical awareness of participating doctors to ensure that the clinical research process complies with ethical principles and relevant laws and regulations.

6 weeks

Research focus and areas:

· Clinical study on laryngeal cancer and hypopharyngeal cancer

· Study on immune memory in nasal inflammation

· The role of type 2 inflammatory associated cells in nasal inflammation

· Clinical study on biological therapy of nasal inflammation

Projects:

1. Study on the role of PI3K/Akt/mTOR signaling pathway and autophagy in the pathogenesis of eosinophilic chronic rhinosinusitis with polyps

2. Role of mirNA155-regulated ILC2s activation in eCRSwNP inflammation and tissue remodeling

3. A randomized, double-blind, placebo-controlled, two-part study evaluating the efficacy and safety of dupliuzumab in patients with uncontrolled chronic sinusitis without nasal polyps (CRSsNP)

Undergraduate students:

Candidates should be enrolled in a bachelor's degree program in clinical medicine or a related field. Basic English skills are required.

Graduate students:

Candidates must be enrolled in a master's, MD or PhD degree program in otolaryngology or a related field. Familiar with research methods and laboratory techniques. Fluency in English is mandatory.

Researcher fellows:

Applicants should have an advanced degree (M.Sc. M.D. Ph.D. or equivalent) in otolaryngology with some prior research experience. Candidates must demonstrate an ability to work independently and contribute to team projects. Proficiency in English is essential.

Doctors:

Candidates must be otolaryngologist with clinical experience. Research experience is not mandatory but is a strong advantage. Applicants must be fluent in English.

Postdocs:

Postdocs should have a doctorate degree in otolaryngology, or equivalent education, training and experience. Candidates should be proficient in English.

Daily Training Schedule:

Monday:

9:00 AM – 12:00 PM: Lecture on Basics of Clinical Research

1:00 PM – 3:00 PM: Main Methods of Clinical Research

Tuesday:

10:00 AM – 12:00 PM: Clinical Trial Design

2:00 PM – 4:00 PM: Clinical Efficacy Study

Wednesday:

9:00 AM –12:00 PM: Diagnostic test studies

2:00 PM – 4:00 PM: Clinical observational study

Thursday

9:00 AM –– 4:00 PM: Clinical research data analysis methods and software introduction

Friday

9:00 AM –– 4:00 PM: Principles of clinical research ethics and application process

Program Training Schedule:

1. Introduction & Welcome

Time Duration: (1 day)

Activities:

· Workshop overview and objectives

· Introduction of facilitators/tutors

2.  Foundational Session

Time Duration: ( 1 week)

Topics:

· Key concepts and theories related to the research focus

· Literature review or background studies

Format: Lecture, interactive Q&A, or multimedia presentations

3. Focused Research Topics

Time Duration: (1 week)

Topics:

· Cutting-edge focus on clinical research research sharing

Format: Interactive lectures, panel discussions, or guest speakers

4. Practical/Hands-On Session

Time Duration: (3 weeks)

Activities:

· Demonstration of research tools or methods such as the use of statistical software

· Practice exercises where participants replicate a research technique

5.Group project

Duration: (1 week)

Events:

· Simulation problem solving for specified topics

· Group projects or brainstorming sessions

· Group presentations and topic discussion

6. Wrap-Up & Reflection

Time Duration: (2 days)

Activities:

· Participant presentations

· Clinical data analysis laboratory exam

· Feedback session (e.g. online survey or live Q&A)

Assessment methods:

· Submission of a final research report summarizing lab work and findings

· Clinical data analysis laboratory exam

· Certificates provided upon successful completion of the program

Feedback:

Participants can submit anonymous feedback via an online form at the end of the program. One-on-one feedback sessions will also be scheduled midway through the program.

The program is free of charge.