This program is designed to provide advanced training in the clinical and molecular research of gynecologic malignancies, with a particular focus on gestational trophoblastic diseases and fertility preservation in cancer patients. Led by Dr. Jianhua Qian, who has over 20 years of experience in gynecologic oncology and has conducted collaborative research with McGill University in Canada, this program offers participants the opportunity to engage in cutting-edge research on the diagnosis, treatment, and fertility preservation strategies for gynecologic cancers.

The program aims to equip early-career researchers with both theoretical knowledge and practical skills in gynecologic oncology, with a special emphasis on the molecular mechanisms of conditions such as hydatidiform mole, invasive mole, choriocarcinoma, and trophoblastic tumors. Additionally, the program focuses on the preservation of fertility in patients with gynecologic malignancies and provides hands-on experience in molecular diagnostics, genetic testing, and clinical trials.

Target participants include graduate students, research fellows, and postdoctoral researchers with a strong interest in gynecologic oncology, reproductive medicine, and translational research. This program will prepare participants for successful academic careers or advanced positions in the biomedical industry, particularly in the fields of oncology and reproductive health.

This program offers a unique opportunity for early-career researchers to gain comprehensive expertise in both clinical and laboratory aspects of gynecologic oncology, with a special focus on rare diseases and fertility preservation.

· Expert Mentorship: Weekly one-on-one mentorship sessions with Dr. Jianhua Qian, a leader in gynecologic oncology, focusing on both clinical and molecular research in gynecologic malignancies and fertility preservation.

· Cutting-edge Research: Access to state-of-the-art laboratory facilities, including molecular genetic testing, gene sequencing, and CRISPR technologies, enabling hands-on experience in cutting-edge gynecologic oncology research.

· Clinical Integration: Direct involvement in ongoing clinical trials and translational research projects, especially in the diagnosis and treatment of rare diseases such as gestational trophoblastic diseases, as well as fertility preservation strategies for cancer patients

· Publication Opportunities: Opportunities to publish research findings in top-tier, peer-reviewed journals and present research at national and international conferences, including those focused on gynecologic oncology and reproductive medicine.

· Comprehensive Research Training: Development of critical thinking, analytical skills, and practical research inquiry, with a focus on the molecular mechanisms of gynecologic malignancies, including hydatidiform mole, choriocarcinoma, and trophoblastic tumors.

· Holistic Research Experience: Training in all aspects of medical research, from study design and data analysis to critical appraisal of literature, providing participants with a well-rounded understanding of the gynecologic oncology research process.

The program aims to empower early-career researchers with the necessary tools, knowledge, and hands-on experience to pursue a successful career in gynecologic oncology research, particularly in the areas of molecular mechanisms, fertility preservation, and the treatment of rare gynecologic cancers.

· Enhance Expertise in Gynecologic Oncology: Provide participants with a comprehensive understanding of the principles and clinical applications in the diagnosis and treatment of gynecologic malignancies, with a particular focus on rare diseases such as gestational trophoblastic diseases (e.g., hydatidiform mole, choriocarcinoma, and trophoblastic tumors).

· Master Advanced Research Techniques: Develop proficiency in cutting-edge laboratory techniques such as gene sequencing, molecular genetic testing, and CRISPR technologies to study the molecular mechanisms of gynecologic cancers and fertility preservation.

· Clinical Trial Competence: Equip participants with the skills necessary to design, analyze, and interpret clinical trials, particularly in the areas of ovarian transplantation and fertility preservation for cancer patients, and the management of gynecologic malignancies.

· Foster Scientific Writing and Research Dissemination: Cultivate skills in scientific writing, including the preparation of research manuscripts, abstracts, and grant applications, to promote successful publication in peer-reviewed journals and presentation at international conferences.

· Advance Fertility Preservation Research: Encourage innovation in the field of fertility preservation for cancer patients by providing hands-on experience with relevant clinical and laboratory studies, contributing to the development of new methodologies and approaches.

· Promote Collaborative and Multidisciplinary Research: Prepare participants to work within multidisciplinary teams, collaborating with experts in oncology, genetics, and reproductive medicine, to drive forward translational research that bridges the gap between laboratory findings and clinical applications.

8 weeks

Research areas:

· Molecular mechanisms underlying gestational trophoblastic diseases, including hydatidiform mole, invasive mole, choriocarcinoma, and trophoblastic tumors.

· New drug treatments and therapeutic strategies for ovarian cancer.

· Ovarian transplantation and fertility protection for female cancer patients.

Projects:

· Screening for genetic mutations in recurrent hydatidiform moles and studying the correlation with fertility outcomes.

· Cellular immunotherapy for advanced multi-drug resistant ovarian cancer

· Ovarian cryopreservation andtransplantation in unmarried and nulliparous women with hematological malinancies

Undergraduate students:

Candidates should be enrolled in a bachelor's degree program in biology, biochemistry, or a related field. Prior coursework in molecular biology or immunology is preferred. Basic proficiency in English is required.

Graduate students:

Candidates must be enrolled in a Master's, M.D. or Ph.D. program in biomedicine, immunology, or a related field. Familiarity with research methodologies and laboratory techniques is required. Fluency in English is mandatory.

Researcher fellows:

Applicants should have an advanced degree (M.Sc. M.D. Ph.D. or equivalent) in a biomedical discipline with some prior research experience. Candidates must demonstrate an ability to work independently and contribute to team projects. Proficiency in English is essential.

Doctors:

Candidates must hold an M.D. degree with clinical experience, preferably in oncology or internal medicine. Research experience is not mandatory but is a strong advantage. Applicants must be fluent in English.

Postdocs :

Postdoctoral fellows should have a Ph.D. in biomedicine, immunology, or an M.D. with clinical training in medicine, or the equivalent of education, training and experience. Candidates should be fluent in English.

Monday:

9:00 AM – 12:00 PM:
Session 1: Introduction & Overview

Key Activities:

· Overview of the program objectives and structure

· Introduction to the research focus: Gynecological malignancies and fertility preservation

· Introduce facilitators, mentors, and program expectations

Format:

Interactive presentation, ice-breaking activities

Tuesday:
9:00 AM – 12:00 PM:
Session 2: Basics of Gynecological Oncology

Topics:

· Introduction to gynecological malignancies (ovarian, cervical, endometrial cancers)

· Current diagnostic and treatment strategies

· Overview of fertility-preserving approaches in gynecological malignancies

Format:

Lecture and group discussions

1:00 PM – 3:00 PM:
Session 3: Advanced Molecular Mechanisms in Gestational Trophoblastic Disease

Topics:

· Molecular mechanisms of hydatidiform moles, invasive moles, choriocarcinoma, and placental site trophoblastic tumors

· Research on familial recurrence and genetic factors, with an emphasis on NLRP7 mutations

· Fertility preservation in gestational trophoblastic disease

Format:

Case study analysis, interactive lecture

Wednesday:
9:00 AM – 12:00 PM:
Session 4: Research Methodology & Data Analysis

Topics:

· Introduction to clinical research methods

· Data collection and analysis for clinical trials in gynecological cancers

· Statistical tools and bioinformatics in cancer research

Format:

Hands-on exercises with statistical software, guided data analysis

1:00 PM – 3:00 PM:
Session 5: Clinical Trials and Translational Research in Ovarian Cancer

Topics:

· Design and implementation of multi-center clinical trials for ovarian cancer

· Latest trends in ovarian cancer therapies and drug development

Format:

Journal club: Reviewing recent research papers

Thursday:
9:00 AM – 12:00 PM:
Session 6: Fertility Preservation and Ovarian Transplantation

Topics:

· Techniques in ovarian cryopreservation and transplantation for cancer patients

· Ethical and clinical considerations in fertility preservation for gynecological cancer patients

· Case studies on fertility outcomes post-ovarian transplantation

Format:

Interactive discussion with case analysis, Q&A session

1:00 PM – 3:00 PM:
Session 7: Laboratory Techniques in Cancer Research

Topics:

· Demonstration of laboratory methods such as PCR, genetic sequencing, and cell culture

· Fertility preservation techniques in laboratory settings

Format:

Practical hands-on workshop

Friday:
9:00 AM – 12:00 PM:
Session 8: Special Topics in Gynecological Oncology

Topics:

· Molecular genetics in gestational trophoblastic diseases

· Cutting-edge research in ovarian cancer immunotherapy

Format:

Guest lecture or panel discussion

1:00 PM – 3:00 PM:
Session 9: Mentorship & Career Development in Research

Topics:

· Research funding strategies, grant writing, and publishing

· Career guidance for aspiring gynecological oncology researchers

Format:

One-on-one mentorship meetings

Program Structure:

Week 1: Introduction & Foundational Concepts

Key topics: Gynecological oncology, molecular mechanisms of gynecological cancers

Format: Lectures, case studies, interactive discussions

Week 2-4: Specialized Research Focus

Key topics: Gestational trophoblastic disease, ovarian cancer clinical trials, molecular research techniques

Format: In-depth exploration of specific diseases, research techniques, hands-on lab work

Week 5-6: Advanced Research Methodology

Key topics: Clinical trials, fertility preservation strategies, data analysis

Format: Workshops, clinical case studies, research paper discussions

Week 7: Collaborative Research & Application

Key topics: Collaborative research methods, presenting research findings

Format: Group projects, mentorship sessions

Week 8: Wrap-Up & Reflection

Key activities: Final research presentations, feedback session

Format: Group presentations, feedback survey, program wrap-up

Expected Outcomes:

· Strong understanding of gynecological oncology research, particularly in fertility preservation

· Proficiency in research methodology, clinical trial design, and data analysis

· Practical experience in laboratory techniques and molecular research methods

· Clear guidance on career development and research funding strategies

Assessment Methods:

1. Final Research Report:

Participants will be required to submit a comprehensive final report summarizing their research activities, key findings, and personal reflections on their learning. The report should demonstrate an understanding of the techniques and research topics covered during the program.

Due Date: End of the program (Week 8)

2. Practical Assessments:

During the wet lab sessions and hands-on workshops, participants will be assessed on their ability to independently perform lab techniques such as PCR, genetic sequencing, cell culture, and bioinformatics analyses.

Format: Observation of participants during practical exercises and feedback from mentors and facilitators.

3. Presentations:

Participants will be required to give a final presentation summarizing their research findings, highlighting key challenges, and discussing their contribution to the field of gynecological oncology.

Format: Oral presentation with PowerPoint slides, followed by Q&A.

Assessment Criteria: Clarity of presentation, depth of research, engagement with the audience, and the ability to answer questions effectively.

4. Participation in Discussions:

Active participation in discussions, journal clubs, and problem-solving activities will be evaluated. Participants are expected to contribute thoughtfully and critically to the research topics and case studies presented.

Format: Group discussions, peer reviews, and mentor feedback during interactive sessions.

5. Mid-Program Evaluation:

A mid-program evaluation will be conducted by mentors to assess the participant's progress in understanding key research concepts, skills acquisition, and overall engagement with the program.

Format: One-on-one mentor meetings to discuss strengths, weaknesses, and future learning goals.

6. Final Evaluation:

The final evaluation will assess the participant's overall performance across all sessions and activities, taking into account practical skills, theoretical understanding, presentation quality, and final report submission.

Format: Overall score based on all assessments, feedback from mentors, and peer reviews.

Certificates and Recognition:

Certificates of completion will be awarded to participants who successfully meet the assessment criteria and demonstrate proficiency in the core areas of the program.

Feedback for Participants:

Participants will have the opportunity to provide anonymous feedback through an online form at the conclusion of the program. This feedback will allow them to share their thoughts on the training content, structure, and overall experience. Additionally, midway through the program, one-on-one feedback sessions will be scheduled with mentors to discuss participants' progress, address any concerns, and offer personalized guidance. This ensures continuous improvement and helps tailor the program to meet the needs of each participant.

The program is free of charge.