Dr. XU Lijun is a consultant at the Department of Infectious Diseases, with a main interest in deciphering mechanisms of host-pathogen interactions and antifungal immune response. He is particularly interested in HIV-associated fungal infection, including HIV-associated cryptococcal meningitis, Cyanobacteria marneffei infection. In addition, HBV infection, bacteria and mycobacterium tuberculosis infection are also his concern.  In the past few years, he has focused his investigation on fungal infection and published his research results on Mediators of Inflammation, Frontiers in Microbiology , Medical Mycology, Infectious Disease, BMC Infectious Diseases, Hepatology, Journal of Clinical Immunology et al. 

Cryptococcus infection

HIV infection and treatment

Viral Hepatitis 

Bacteria and TB infection

Invited Speaker of Chinese AIDS Conference (5th, Kunmig, China and 6th,Hangzhou,China)

Special Invited Speaker of Chinese HIV/HCV Conference (10th,Chendu，China)

Outstanding doctor for HIV treatment in Zhejiang Province

Member of clinical treatment council, Chines Society of STD and AIDS

Member of AIDS council of Tropical Disease, Chinese Medical Association

Publications

1. Zhao, H., Zhou, M., Zheng, Q., Lang, G., & Xu, L. (2021). Immune status affects the clinical features and outcomes of adult patients with respiratory adenovirus infection. Epidemiology and Infection, 149, E235(corresponding author）

2. Xu L, Zhao H, Zhou M, Lang G and Lou H (2021) Single and Repeated Episodes of Candida Species Isolated From Cerebrospinal Fluid for Diagnosing Probable Candida meningitis. Front. Microbiol. 12:742931.

3. Xu L, Xu Y, Zheng Y, Peng X, Yang Z, Cao Q, Xiang D, Zhao H. Differences in cytokine and chemokine profiles in cerebrospinal fluid caused by the etiology of cryptococcal meningitis and tuberculous meningitis in HIV patients. Clin Exp Immunol. 2021 Oct;206(1):82-90. 

4. Zhao H, Zhou M, Zheng Q, Zhu M, Yang Z, Hu C, Xu L. Clinical features and Outcomes of Cryptococcemia patients with and without HIV infection. Mycoses. 2021 Jun;64(6):656-667. (corresponding author）

5. Xu L, Yu J, Zheng B, et al. HIV Infection Does Not Increase 10-Week Mortality of Chinese Cryptococcal Meningitis Patients. AIDS Res Hum Retroviruses. 2020 Sep;36(9):734-741.

6. Xu L, Guo Y, Zhao Y, Xu Y, Peng X, Yang Z, et al. Chemokine and Cytokine Cascade Caused by Skewing of the Th1-Th2 Balance Is Associated with High Intracranial Pressure in HIV-Associated Cryptococcal Meningitis. Mediators of Inflammation 2019,2019:1-9.

7. Xu L, Tao R, Wu J, Dai X, Hu C, Huang Y, et al. Short-Course Rather Than Low-Dose Amphotericin B May Exert Potential Influence on Mortality in Cryptococcal Meningitis Patients Treated With Amphotericin B Plus Flucytosine Alone or in Combination With Fluconazole. Frontiers in microbiology 2019,10:2082-2082.

8. Xu L, Zhang X, Guo Y, Tao R, Dai X, Yang Z, et al. Unique clinical features of cryptococcal meningitis among Chinese patients without predisposing diseases against patients with predisposing diseases. Medical mycology 2019,57:944-953.

9. Xu L, Tao R, Zhao Q, Cheng J, Zhu B. An AIDS patient with urine retention. BMC infectious diseases 2019,19:1051-1051.

10. Xu L, Hu C, Hu H, Dai X, Gao H, Guo Y, et al. Importance of fibrosis 4 index score and mode of anti-fungal treatment to the outcome of Cryptococcal meningitis in hepatitis B virus-infected patients. Infect Dis (Lond) 2019,51:113-121.

11. Xu Lijun ; Zhu Biao; Huang Ying; Yang Zongxing; Sun Jia; Xu Yan; Zheng Jinlei; Kinloch Sabine; Yin Michael T.; Weng Honglei; Wu Nanping(*). Butyrylcholinesterase Levels on Admission Predict Severity and 12-Month Mortality in Hospitalized AIDS Patients , Mediators of Inflammation, 2018, 5201652:0~5201652

12.  Peng X, Li-Jun X, Xie T, Liu F, Wu N. Near Full-Length Genome Identification of a Novel HIV-1 Recombinant Form (CRF01_AE/CRF07_BC) in Zhejiang, China. AIDS Res Hum Retroviruses. 2016 Sep;32(9):900-3 （co-first author）

13. Xu L, Ye H, Huang F, Yang Z, Zhu B, Xu Y, Qiu Y, Li L. Moderate/Severe hyponatremia increases the risk of death among hospitalized Chinese human immunodeficiency virus/acquired immunodeficiency syndrome patients. PLoS One.;9(10):e111077，2014

14. Xu L, Li Q, Ye H, Zhang Q, Chen H, Huang F, Chen R, Zhou R, Zhou W, Xia P, Chen Y, Pan C. The Nine-Repeat DC-SIGNR Isoform is Associated with Increased HIV-RNA Loads and HIV Sexual Transmission. J Clin Immunol. 30(3):402-7. 2010.

15. Li-Jun X, Brockmeyer NH, Bader A, Hang-Ping Y, Zhi-Gang W, Nanping W. HIV-1 Infected Germans have more Variations on Neck Region of DC-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin （DC－SIGN）than HIV-1 infected Chinese. Eur J Med Res;13(2):59-62, 2008.

16. Li-Jun Xu，Xiu-Chun Chang，Hang-Ping Yao，Nan-Ping Wu. NF-êBp50 is associated with DC-SIGN expression induced by IL-4 in THP-1 cells. Prog Biochem Biophys. 35(1):50-55, 2008.

17. Xu LJ, Yao HP, Li D, Wang ZG, Chen L, Wu NP. Variations of Dendritic Cell-specific Intercellualar Adhesion Molecule-3-Grabing Nonintegrin neck region in HIV infected individuals. Chin Med J. 121(3):265-7,2008.

18. Xu LJ, Yao HP, Fan J, Li D, Wu NP. Production of monoclonal antibodies against phosphoprotein 65 from human cytomegalovirus. Hybridoma (Larchmt).26(3):173-7,2007