Dr. ZHENG holds a PhD and serves as Chief Technician, Distinguished Research Fellow, Associate Professor, Doctoral Supervisor. Deputy Director of the Department of Laboratory Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Deputy Director of the Zhejiang Key Laboratory of Clinical In Vitro Diagnostic Techniques. He is recipient of the Zhejiang Provincial Outstanding Youth Science Fund, and has been selected for the Zhejiang Provincial Medical Rising Star Program and the Clinical Top Talent Program of Zhejiang University School of Medicine. He serves as Vice Chair of the Youth Committee of the Chinese Medical Doctor Association's Laboratory Medicine Branch, Member of the Youth Committee of the Chinese Medical Association of Laboratory Medicine Branch and Vice Chair of the Zhejiang Provincial Medical Association of Laboratory Medicine Branch. He was a Visiting Scholar at Monash University, Australia. 

He is mainly engaged in research on pathogenic diagnosis of infectious diseases and mechanisms of disease severity progression. He has led three National Natural Science Foundation of China projects, including the Original Exploration Program, and one sub-project under the National Key R&D Program. He has published over 30 SCI-indexed papers as first or corresponding author (including co-authorship) in journals such as BMJ and Advanced Science. As a key contributor, he received one Special Prize of the National Science and Technology Progress Award, one First Prize of the Chinese Medical Science and Technology Award, and one Second Prize of the Ministry of Education's Technological Invention Award.

Pathogenic diagnosis of infectious diseases

Mechanisms of disease severity progression.

1. Han D, Yu F, Zhang D, Hu J, Zhang X, Xiang D, Lou B, Chen Y*, Zheng S*. Molecular rapid diagnostic testing for bloodstream infections: Nanopore targeted sequencing with pathogen-specific primers. J Infect. 2024 Jun;88(6):106166. doi: 10.1016/j.jinf.2024.106166.

2. Han D*, Liu C, Yang B, Yu F, Liu H, Lou B, Shen Y, Tang H, Zhou H*, Zheng S*, Chen Y*. Metagenomic fingerprints in bronchoalveolar lavage differentiate pulmonary diseases. NPJ Digit Med. 2025 Oct 7;8(1):599. doi: 10.1038/s41746-025-01977-5.

3. Shen Y*, Qu W, Song M, Zhang T, Liu C, Shi X, Xu X, Jiang J, Ding L, Mo F, Mao Z, Huang M, Xu Z, Chen J, Shen E, Ruan J, Liu J, Timko MP, Chen Y, Fan L, Zheng S*, Wang Y*. Single-microbe RNA sequencing uncovers unexplored specialized metabolic functions of keystone species in the human gut. Imeta. 2025 Apr 17;4(3):e70035. doi: 10.1002/imt2.70035.

4. Shen Y, Yu F, Zhang D, Zou Q, Xie M, Chen X, Yuan L, Lou B, Xie G, Wang R, Yang X, Chen W, Wang Q, Feng B, Teng Y, Dong Y, Huang L, Bao J, Han D, Liu C, Wu W, Liu X, Fan L, Timko MP, Zheng S*, Chen Y*. Dynamic Alterations in the Respiratory Tract Microbiota of Patients with COVID-19 and its Association with Microbiota in the Gut. Adv Sci (Weinh). 2022 Sep;9(27):e2200956. doi: 10.1002/advs.202200956.

5. Zheng S, Fan J, Yu F, Feng B, Lou B, Zou Q, Xie G, Lin S, Wang R, Yang X, Chen W, Wang Q, Zhang D, Liu Y, Gong R, Ma Z, Lu S, Xiao Y, Gu Y, Zhang J, Yao H, Xu K, Lu X, Wei G, Zhou J, Fang Q, Cai H, Qiu Y, Sheng J, Chen Y, Liang T. Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study. BMJ. 2020 Apr 21;369:m1443. doi: 10.1136/bmj.m1443.

6. Zheng S, Zou Q, Wang X, Bao J, Yu F, Guo F, Liu P, Shen Y, Wang Y, Yang S, Wu W, Sheng J, Vijaykrishna D, Gao H, Chen Y. Factors Associated With Fatality Due to Avian Influenza A(H7N9) Infection in China. Clin Infect Dis. 2020 Jun 24;71(1):128-132. doi: 10.1093/cid/ciz779.

7. Zheng S, Tang L, Gao H, Wang Y, Yu F, Cui D, Xie G, Yang X, Zhang W, Ye X, Zhang Z, Wang X, Yu L, Zhang Y, Yang S, Liang W, Chen Y, Li L. Benefit of Early Initiation of Neuraminidase Inhibitor Treatment to Hospitalized Patients With Avian Influenza A(H7N9) Virus. Clin Infect Dis. 2018 Mar 19;66(7):1054-1060. doi: 10.1093/cid/cix930.

8. Yang J^#, Zheng S^#, Sun J^#, Wu H, Zhang D, Wang Y, Tian T, Zhu L, Wu Z, Li L, Gao GF, Bi Y, Yao H. A human-infecting H10N5 avian influenza virus: Clinical features, virus reassortment, receptor-binding affinity, and possible transmission routes. J Infect. 2025 Apr;90(4):106456. doi: 10.1016/j.jinf.2025.106456.

9. Lou B^#, Li TD^#, Zheng SF^#, Su YY^#, Li ZY, Liu W, Yu F, Ge SX, Zou QD, Yuan Q, Lin S, Hong CM, Yao XY, Zhang XJ, Wu DH, Zhou GL, Hou WH, Li TT, Zhang YL, Zhang SY, Fan J, Zhang J, Xia NS, Chen Y. Serology characteristics of SARS-CoV-2 infection after exposure and post-symptom onset. Eur Respir J. 2020 Aug 27;56(2):2000763. doi: 10.1183/13993003.00763-2020.

10. Feng B^#, Xu K^#, Gu S^#, Zheng S^#, Zou Q, Xu Y, Yu L, Lou F, Yu F, Jin T, Li Y, Sheng J, Yen HL, Zhong Z, Wei J, Chen Y. Multi-route transmission potential of SARS-CoV-2 in healthcare facilities. J Hazard Mater. 2021 Jan 15;402:123771. doi: 10.1016/j.jhazmat.2020.123771.

Vice Chair of the Youth Committee of the Chinese Medical Doctor Association's Laboratory Medicine Branch

Member of the Youth Committee of the Chinese Medical Association of Laboratory Medicine Branch

Vice Chair of the Zhejiang Provincial Medical Association of Laboratory Medicine Branch