NHCPRC Key Laboratory of Combined Multi-organ Transplantation was established in 2000 based on the First Affiliated Hospital of Zhejiang University School of Medicine. Under the leadership of Academician Zheng Shusen, the director of the laboratory, the laboratory conducted innovative research on the key bottlenecks faced in the development of organ transplantation in China, constructed a basic theoretical system of organ transplantation, and promoted it in clinical practice. The main research directions of the key laboratory are: 1. Prevention and treatment of relapse of primary disease after transplantation; 2. Mechanism and intervention of Chronic Graft Dysfunction (CGD) after organ transplantation; 3. Application of source and quality protection of donor organs.

After nearly 20 years of development, the laboratory has created a world-class organ transplantation research platform system, including transplant immunity, donor organ perfusion protection, transplant model animals, bioinformatics research platform for bioinformatics, SPF experimental animal center, and digital experiments Laboratory management system and large-scale clinical sample resource database system. A high-level scientific research and clinical translational research team composed of academicians, Yangtze River scholars and scholars of National Distinguished Youth Fund has been cultivated.

In recent years, laboratory members have undertaken more than 100 national scientific research projects, including two 973 projects (the Major State Basic Research Development of China) as chief scientist, three innovation group projects of the National Natural Science Foundation of China, one Distinguished Young Scholar project of the National Natural Science Foundation and one Excellent Youth Scholars project of Ministry of Education of China, two Key Program and Major Programs of the National Natural Science of China , four major infectious diseases programs, three 863 projects (the National High Technology Research and Development Program of China). Laboratory members have published more than 400 SCI papers in journals such as Nature and Gut, formulated 6 industry guidelines and expert consensus, won 1 Innovation Team Award, 1 first prize and 2 second prizes of the National Science and Technology Progress Award, 7 first prizes of Scientific and Technological Progress Award of Zhejiang Province, have led the development of organ transplantation in China.